{"id":1595,"date":"2021-03-29T09:56:14","date_gmt":"2021-03-29T09:56:14","guid":{"rendered":"https:\/\/orthobiologicsassociates.com\/?page_id=1595"},"modified":"2024-06-19T19:49:59","modified_gmt":"2024-06-19T19:49:59","slug":"clinical-research","status":"publish","type":"page","link":"https:\/\/orthobiologicsassociates.com\/clinical-research\/","title":{"rendered":"Clinical Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.20.2″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Clinical Research<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||25px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_font=”|600|||||||” header_4_line_height=”2em” custom_margin=”||14px|||” global_colors_info=”{}”]<\/p>\n

ORTHOPEDIC (OSTEOARTHRITIS & INJURIES)<\/h4>\n

[\/et_pb_text][et_pb_divider color=”#1B76BC” divider_weight=”3px” _builder_version=”4.16″ _module_preset=”default” width=”300px” custom_margin=”||18px|||” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_font=”|600|||||||” header_4_line_height=”2em” global_colors_info=”{}”]Mesenchymal stem cells (MSCs) are self-renewing, multi-potent, progenitor cells with multi-lineage potential to differentiate into cell types of mesodermal origin. Due to this attribute, MSCs can differentiate into chondrocytes, which are later replaced by bone. This attribute repairs the subchondral bone without any loss of articular cartilage at the surface.<\/p>\n

MSCs have shown to therapeutically alter the progression of OA by down-modulating the release and expression of the main OA inflammatory factors and chemokines (signaling proteins secreted by cells) directly involved in the progression of the disease. Additionally, there has been significant improvement in joint function through pain reduction and increase of cartilage in the affected joint.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2021\/05\/female-patient-examining-spine-physiotherapist-vertebrology-center-scaled.jpg” alt=”Orthopedic Injuries” title_text=”Physiotherapist At Vertebrology Center” _builder_version=”4.16″ _module_preset=”default” animation_style=”slide” animation_direction=”left” animation_duration=”1400ms” animation_intensity_slide=”10%” hover_transition_duration=”400ms” hover_transition_speed_curve=”ease-in-out” global_colors_info=”{}” transform_styles__hover_enabled=”on|hover” transform_scale__hover_enabled=”on|hover” transform_translate__hover_enabled=”on|desktop” transform_rotate__hover_enabled=”on|desktop” transform_skew__hover_enabled=”on|desktop” transform_origin__hover_enabled=”on|desktop” transform_scale__hover=”104%|104%”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#f9f9f9″ background_image=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2021\/03\/therapist-12-1.png” custom_padding=”45px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_font=”|600|||||||” header_4_text_align=”center” header_4_font_size=”32px” custom_margin=”||10px|||” global_colors_info=”{}”]<\/p>\n

Read Our Articles<\/h4>\n

[\/et_pb_text][et_pb_divider color=”#1B76BC” divider_weight=”3px” _builder_version=”4.16″ _module_preset=”default” width=”300px” module_alignment=”center” custom_margin=”||18px|||” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”A Randomized Controlled Trial Of The Treatment Of Rotator Cuff Tears With Bone Marrow Concentrate.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”ACL Tear Treated With BMAC.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Adult Mesenchymal Stem Cells For The Treatment In Patients With Rotator Cuff Disease.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Increased Knee Cartilage Using Stem Cells.Pdf ” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Knee Cartilage Repair Review 2019″ use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Treatment Of Shoulder Osteoarthritis And Rotator Cuff Tears With Bone Marrow Concentrate And Whole Bone Marrow Injections.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”A Prospective, Single-Blind, Placebo-Controlled Trial Of Bone Marrow Aspirate Concentrate For Knee Osteoarthritis” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Knee Osteoarthritis A Randomized Controlled Trial With 2 Year Follow Up.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Mesenchymal Cell Therapy Ortho-Biologics In The Treatment Of Hip Osteoarthritis.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Mesenchymal Stem Cells Injection In Hip Osteoarthritis.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Cell Therapy Ortho-Biologics In The Management Of Shoulder Rotator Cuff Disorders.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”The Healing Effect Of Bone Marrow Derived Stem Cells In Knee Osteoarthritis.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#1B76BC” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#f6f7f7″ background_image=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2021\/04\/image.png” parallax=”on” parallax_method=”off” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” header_4_font=”|600|||||||” header_4_text_color=”#FFFFFF” header_4_line_height=”2em” global_colors_info=”{}”]<\/p>\n

DEGENERATIVE DISC DISEASE<\/h4>\n

Adipose derived Cell Therapy<\/a> Ortho-Biologics uses Mesenchymal Stem Cells (MSCs) to significantly display long-term proliferation, efficient self-renewal, and multi-potent differentiation. Meaning the MSCs have the ability to end and reverse degeneration of spinal discs. More specifically through increasing disc height by 23.6%, disc water content, and gene expression. One of the main biological functions of MSCs is their ability to reproduce cartilage and bone tissue cells (multi-potent differentiation capability). This is important in degenerative disc disease, since a large number of cells from the outer ring (annulus fibrosus) and the inner gelatinous (nucleus pulposus) of the discs are of a cartilaginous nature.[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2020\/04\/Autologous-Bone-Marrow-Concentrate-Cells-Significantly-Reduces-Lumbar-Discogenic-Pain-Through-12-Months.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Stem Cell Treatment For Discogenic Low Back Pain And Disc Degeneration.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2020\/04\/Stem-Cell-Treatment-for-Discogenic-Low-Back-Pain-and-Disc-Degeneration.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Stem Cells Sources For Intervertebral Disc Regeneration.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2020\/04\/Stem-cells-sources-for-intervertebral-disc-regeneration.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Treatment Of Lumbar Degenerative Disc Disease-Associated Radicular Pain With Autologous Stem Cells.” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/orthobiologicsassociates.com\/wp-content\/uploads\/2020\/04\/Treatment-of-lumbar-degenerative-disc-disease-associated-radicular-pain-with-autologous-stem-cells.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Stem Cells In Preclinical Spine Studies” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/media-cdn.nsistemcell.com\/wp-content\/uploads\/2018\/12\/Stem-cells-in-preclinical-spine-studies.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Cell Therapy For Age Related Intervertebral Disc Pathologies Disc” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/media-cdn.nsistemcell.com\/wp-content\/uploads\/2018\/12\/Cell-Therapy-for-age-related-inte-disc.pdf” global_colors_info=”{}”][\/et_pb_blurb][et_pb_blurb title=”Therapy For Degenerative Disc Disease” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_font_size=”17px” header_line_height=”1.3em” custom_margin=”||7px||false|false” link_option_url=”https:\/\/media-cdn.nsistemcell.com\/wp-content\/uploads\/2018\/12\/Treatment-of-Degenerative-Disc-Disease.pdf” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Clinical ResearchORTHOPEDIC (OSTEOARTHRITIS & INJURIES)Mesenchymal stem cells (MSCs) are self-renewing, multi-potent, progenitor cells with multi-lineage potential to differentiate into cell types of mesodermal origin. Due to this attribute, MSCs can differentiate into chondrocytes, which are later replaced by bone. This attribute repairs the subchondral bone without any loss of articular cartilage at the surface. MSCs […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"two_page_speed":{"current_score":{"desktop_score":97,"desktop_tti":"0.7\u00a0","mobile_score":89,"mobile_tti":"2.8\u00a0","date":"19.06.2024 07:50:31 pm","status":"completed"}},"footnotes":""},"class_list":["post-1595","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nRegenerative Medicine Clinical Research | Orthobiologics Associates<\/title>\n<meta name=\"description\" content=\"Adipose-derived Cell Therapy Ortho-Biologics uses Mesenchymal Stem Cells (MSCs) to significantly display long-term proliferation, efficient self-renewal, and multipotent differentiation. 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